Mitochondria control of physiology and disease: beyond ATP

Mitochondria control of physiology and disease: beyond ATP

Mitochondria control of physiology and disease: beyond ATP

Air date: Wednesday, March 7, 2018, 3:00:00 PM

Category: WALS – Wednesday Afternoon Lectures

Runtime: 00:57:53

Description: NIH Director’s Wednesday Afternoon Lecture Series

Historically, mitochondria have been primarily viewed as biosynthetic and bioenergetic organelles that generate metabolites for the production of macromolecules and adenosine triphosphate (ATP), respectively. The work of the Chandel laboratory has elucidated that mitochondria have a third distinct role whereby they release reactive oxygen species (ROS) and metabolites to regulate transcription factors and epigenetics. For his lecture, Dr. Chandel will present his lab’s ongoing efforts to understand how mitochondria, in addition to producing ATP, regulate cancer and immunity.

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Author: Navdeep S. Chandel, Ph.D., David W. Cugell Professor of Medicine, Northwestern University

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8 Replies to “Mitochondria control of physiology and disease: beyond ATP”

  1. Could selective mitochondrial Autophagy combined with mitochondrial biogenesis be used to develop a cure for Mitochondrial diseases?
    that if there is a way to to make Parkin-Pink1 bind to the autophagy receptor without ROS inside the mutant mitochondria. i know ROS causes the Parkin-Pink1 to bind to the autophagy receptor of damaged mitochondria due to lots of ROS being produced from ATP synthesis as a sort of by product of ATP synthesis. are any super tiny ligands or artificial molecular ligands that could be be used to make Parkin-Pink1 bind to the autophagy receptors. And is there a difference between universal Autophagy receptors and selective autophagy? i would really be interested in hearing what Dr. Dave Chan has to say about autophagy being used to develop a treatment for mitochondrial diseases.

  2. Isn’t it funny how just right after all these scientists finds out that Metformin cures cancer, that Metformin gets recalled…. lol

  3. Mitochondrial cannabinoid receptor one regulates complex 1 activity

    Allows for adequate atp while down regulating (excess) mitoROS production

    🙂 happy to be first

  4. This was great, I have been researching "mitochondrial function for kids" for a while now, and I think this has helped. Have you ever come across – Miyason Mitochondria Masker – (do a search on google ) ? Ive heard some interesting things about it and my neighbour got amazing results with it

  5. If you really want to control cancer, heart disease or ANY chronic disease you must focus on ENDING your own cold, flu and 100+ so called common symptoms. It’s not complicated. It is about WHAT YOU EAT. Period.

  6. Not sure if I understood correctly, but On the Smart Drug Smarts episode #226, Navdeep mentions there’s ~10 copies of the mitochondria dna inside a single mitochondria cell.. and, aside from red blood cells, there are anywhere between1500 to 100,000+ mitochondrial cells inside a single human cell (depending on the cell function), is that correct?

    Also, not only do Mitochondrial mutations (PINK1, PARKIN, etc) lead to energy deficiencies that give rise to specific diseases (Parkinson’s, periodontal, etc).. but they also are responsible for aging symptoms in general, where the somatic mutations accumulate eventually damaging tissues. Interestingly, Aubrey de Grey suggests mitochondrial damage is not the single most dominant cause of senescence.

    Is there anything to maximize mitochondria health and reduce excess ROS and/or promote proper autophagy? Infrared exposure? Vitamin K2? Elysium’s NAD+ product, Basis? Endurance vs intensity exercises? Keto diet? BaCopa, Phosphatidyslerine, Pycnogenol, CDP Choline, and BioPQQ / Sulbutiamine (synthetic version of Vitamin B1 Thiamine)?

    There’s also a couple great resources.. ‘mRNA to protein’ on the Khan Academy channel.. Dr. Lee Know interview on the 40+ Fitness podcast… Radiolabs’ The Primordial Journey series, and finally Dr. Douglas Wallace on the recent Stem Talk podcast. In the latter, it’s mentioned that mitochondria started as proteobacteria that formed a symbiotic relationship with archaebacteria, deep in the ocean, transferring all but 37 of it’s 1500 genes over to the nucleus dna (1h7m18s)!

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